topoisomerase单词基本解析：

局部异构酶
n. [化]拓扑异构酶, 局部异构酶
释义局部异构酶；

topoisomerase变化用词：

topoisomerase英英释义：

TopoisomeraseTopoisomerases (type I: , type II: ) are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double helical structure.

以上来源于:Wikipedia

topoisomerase中文词源：

topoisomerase用法和例句：

topoisomerase

Chromosomally mediated multidrug resistance in Salmonella typhimurium is generally attributed to the overexpression of the acrAB locus and the mutation in topoisomerase genes.

AcrAB外流泵系统的过度表达和拓扑异构酶基因突变是导致鼠伤寒沙门菌产生多重耐药性 (MAR)的重要原因。

Type I DNA topoisomerase

DNAⅠ型局部异构酶

Type II DNA topoisomerase

DNAⅡ型局部异构酶

DNA topoisomerase -Ⅱ

DNA拓扑异构酶-Ⅱ

Keywords DNA topoisomerase;Cancers;Cell proliferative index;

DNA拓扑异构酶;肿瘤;细胞增生标记物;

DNA Topoisomerase Ⅰ

DNA拓扑异构酶Ⅰ

DNA topoisomerase Ⅱ

DNA拓扑异构酶Ⅱ

DNA topoisomerase Ⅱ alpha (DNA TopoⅡα)

DNA拓扑异构酶Ⅱα

DNA topoisomerase inhibitor

DNA拓扑异构酶抑制剂

Apoptosis caused in HL60 cells by camptothecin (topoisomerase inhibitor).Images of nuclei in mid apoptosis Apoptosis caused in HL60 cells by camptothecin (topoisomerase inhibitor).

Images of nuclei in late apoptosis 本站所有图书及资料均可在子午学术论坛得到应助下载。

Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule.

rar[Download](说明: )本站所有图书及资料均可在子午学术论坛得到应助下载。

T4 DNA topoisomerase

T4 DNA拓扑异构酶

topoisomerase I-interacting protein(TOPORS)

TOPORS

topoisomerase Ⅱ (TOPⅡ)

TOPⅡ（拓扑异构酶）

DNA topoisomerase

[化] DNA拓扑异构酶

Keywords Salmonella typhimurium;Drug Tolerance;Mutation;DNA Topoisomerase（ATP-Hydrolysing）;

关键词沙门氏菌;鼠伤寒;药物耐受性;突变;DNA拓扑异构酶（ATP水解）;

Onodera Y,Okuda J,Tanaka M,et al.Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV of enterococcus faecalis[J].Antimicrob Agents Chemother,2002,46(6):1800.

刘志远许淑珍马纪平.肠球菌庆大霉素高水平耐药机理的研究进展[J].中华检验医学杂志,2004,27(4):266-268,.

Expression of DNA topoisomerase in ovarian serous and mucinous cystadenocarcinomas

卵巢浆液性、黏液性囊腺癌DNA拓扑异构酶的表达

The raw materials plant resources of topoisomerase inhibitors were investigated, which provided basic data for the exploitation and utilization of these resources.

对昆奇山拓扑异构酶抑制刑的植物资源进行了调查，为该资源的开发利用提供基础资料。

The clinical significance of DNA topoisomerase expression in acute lymphoblastic leukemia

急性淋巴细胞白血病患者DNA拓扑异构酶的表达及临床意义

Inhibition of Topoisomerase I

抑制拓扑异构酶

The inhibition of topoisomerase IV exacerbated these effects (45) .

抑制拓扑异构酶四加剧这些影响（ 45 ） 。

Inhibitor of cyclic adenosine 3’,5’-monophosphate phosphodiesterase and topoisomerase ITopo I).

抑制环腺苷3’,5’-一磷酸盐磷酸二酯酶和拓扑酶I。

DNA topoisomerase ( DNA TopoⅡ)

拓扑异构酶

Topoisomerase - Ⅱ

拓扑异构酶-Ⅱ

topoisomerase 1 inhibitor

拓扑异构酶1抑制剂

Topoisomerase Ⅰ

拓扑异构酶Ⅰ

Topoisomerase inhibitorl

拓扑异构酶Ⅰ抑制剂

Topoisomerase Ⅱ

拓扑异构酶Ⅱ

Topoisomerase Ⅱα

拓扑异构酶Ⅱα

topoisomerase Ⅱβ

拓扑异构酶Ⅱβ

Topoisomerase Ⅲα

拓扑异构酶Ⅲα

topoisomerase Ⅳ

拓扑异构酶Ⅳ

type I topoisomerase

拓朴异构体酶Ⅰ型

type II topoisomerase

拓朴异构体酶Ⅱ型

Topoisomerase 2 resolves hyperpositively supercoiled DNA before recombination forks and topoisomerase 3 resolves hypernegatively supercoiled DNA after recombination forks.

拓朴异构酶可以解开在重组叉之前高度正螺旋结构，拓朴异构酶3可以解开重组叉之后高度负螺旋结构。

It suggested that the level of resistance of isolates would be related to selecting pressure of fluoroquinolones and induced gene mutations of DNase and topoisomerase IV could not activate AcrAB efflux pump system.

提示临床分离的鸡大肠杆菌O 78的耐药水平与喹诺酮类药物的选择性压力有关,它诱导了DNA旋转酶和拓扑异构酶IV的基因突变,可能不能激活A crAB外输泵。

Topoisomerase exists commonly in the living nature.It is the key material that directly participates in or influences DNA.

摘要拓扑异构酶在生物界中普遍存在，它是直接参与或影响DNA的关键性物质。

Most STR has no function of coding, maybe they have activating matter, recombination site and the function of combining site of DNA topoisomerase.

本文对呼吸道合胞病毒感染和腺病毒感染的患儿STR改变进行研究，发现病毒感染后D5S818基因座等位基因频率与正常新生儿对照组有明显差异。

This review highlights some recent progresses in the studies of DNA recognition, cleavage and topoisomerase inhibition with ruthenium(II) polypyridyl complexes.

本文简要评述了钌(II)多吡啶配合物在DNA识别、断裂及拓扑异构酶抑制方面的研究情况。

DDB was also found to inhibit topoisomerase II activity of Bel-74 02 hepatocarcinomacells.

此外，DDB还能降低从Bel－7402细胞内提取出的DNA拓扑异构酶II（ToPoII）活力。

Salvicine, a novel diterpenoid quinone compound identified as a nonintercalative topoisomerase II poison, possesses a broad range of antitumor and antimetastatic activity.

沙尔威辛是一种新型的二萜醌类的非嵌入性拓扑异构酶II毒剂，具有良好的抗肿瘤和抗转移作用。

Topoisomerase I then ligates the PCR product in the correct orientation.

然后拓扑异构酶I将PCR产物按照正确的方向连接。

Topoisomerase inhibitors

白血病

Keywords Leukemia/drug therapy;Alkylating agents;Topoisomerase II inhibitors;Chloramphenicol;Karbamazpine;

白血病/药物疗法;烷化剂;拓扑异构酶II抑制剂;氯霉素;马西平;

Keywords leukemia;multidrug resistance;etoposide;topoisomerase II;transcription factor Specificity protein;proliferate;apoptosis;

白血病;多药耐药;足叶乙甙;拓扑异构酶II;转录因子特化蛋白;增殖;凋亡;

Objective:To evaluate the effect of cisplatin(DDP) and hydroxycamptothecin (HCPT) as inhibitors of DNA topoisomerase combined with radiotherapy for nasopharyngeal carcinoma (NPC).

目的:探讨DNA拓扑异构酶抑制剂羟基喜树碱(HCPT)与顺铂(DDP)联合治疗鼻咽癌的价值。

It is reported that DNA topoisomerase has a high expression level, which related with the mechanism of many antitumor drugs.

研究发现,拓扑异构酶在肿瘤组织中高表达,许多抗肿瘤药物的作用机制与抑制拓扑异构酶有关。

twisting topoisomerase

紧旋拓扑异构酶

Keywords Shikonin;DNA topoisomerase I;K562 leukemia cells;Apoptosis;

紫草素;DNA拓扑异构酶I;K562白血病细胞;凋亡;

It is concluded that the nuclear focus formation of hMRE11 protein may be a response to DNA damage induced by topoisomerase II inhibitor VP-16 in human promonocytic cell line U937.

结论:hMRE11蛋白核灶形成可能参与VP-16所致人单核白血病细胞株U937的DNA损伤修复过程。

Keywords Lung cancer Multidrug resistance Drug selection P-glycoprotein Multidrug resistance-associated protein Lung resistance protein Glutathione S transferases DNA topoisomerase;

肺癌;多药耐药;药物筛选;P-糖蛋白;多药耐药相关蛋白;肺耐药蛋白;谷胱苷肽S转移梅;DNA拓扑异构酶;

Keywords Yuanhuacine;Daphne Diterpene Esters;Daphne genkwa;Antitumor Mechanism;Inhibitory Activity against DNA topoisomerase I;

芫花酯甲;瑞香烷型二萜原酸酯;芫花;抗癌作用机理;DNA拓扑异构酶I抑制剂;

Topoisomerase type I cuts one strand whereas topoisomerase type II cuts both strands of the DNA to relax the coil and extend the DNA molecule.

超螺旋DNA分子在凝胶电泳中比其它类型移动速度快，只相差一个超螺旋，就可以在凝胶电泳中分开。

Keywords Pseudomonas aeruginosa;Quinolone;Resistance mechanism;Mutation of type II topoisomerase gene;Active efflux;multidrug resistance;Bacterial biofilm;

铜绿假单胞菌;喹诺酮;细菌耐药机制;拓扑异构酶II基因突变;主动外排多重耐药;细菌生物膜;

用作名词(n.)

The raw materials plant resources of topoisomerase inhibitors were investigated, which provided basic data for the exploitation and utilization of these resources.
对昆奇山拓扑异构酶抑制刑的植物资源进行了调查，为该资源的开发利用提供基础资料。

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