telomerase是什么意思 telomerase怎么读
英式：[tə'lɒməreɪz]
美式：[tə'lɒməreɪz]
telomerase单词基本解析：
n.端粒酶n. 未端酶, 端粒酶
n.端粒酶；
telomerase变化用词：
telomerase英英释义：
Noun1. an enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide
名词 telomerase:
an enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide
telomerase[ te'lɔməreis ]n.an enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide
telomerase中文词源：
telomerase用法和例句：
Abstract: Objective To investigate telomerase activity in patients with psoriasis.
文摘: 目的探讨银屑病的端粒酶活性表达情况.
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Conclusion: Down - regulating the telomerase activity may be responsible for its anti - cancer mechanism.
结论: 下调肿瘤细胞的端粒酶活性,可能是半枝莲 抗肿瘤 的重要机制之一.
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Objective : To explore the relation between telomerase activity and tumor biology.
目的: 探讨端粒酶活性与肿瘤生物学关系.
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Their research showed that cells age if telomerase telomeres are shortened.
他们的研究显示如果端粒缩小,细胞将老化.
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Conclusion Telomere reduction and telomerase activation are critical factor during oncogenesis.
结论端粒缩短并激活端粒酶是涎腺肿瘤形成的重要因素.
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Objective : To explorethe composition, struction and activity regulative mechanism of telomerase.
目的综述端粒酶的组成 、 结构及其活性调节机制.
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To her surprise, she found no correlation between telomerase and longevity.
她惊奇地发现,端粒酶与寿命并不存在相关性.
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Results: Telomerase is a reverse transcriptase comprised of many subunit.
结果端粒酶是一多亚基复合物,具有逆转录酶活性.
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The detection of telomerase may be helpful to gastric cancer early.
追踪端粒酶阳性的胃癌前病变患者有利于早期发现胃癌.
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Telomerase system is the genetic name of telomerase and telomere.
端粒酶系统是端粒和端粒酶的总称.
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Objective To investigate telomerase activity in patients with psoriasis.
目的探讨银屑病的端粒酶活性表达情况.
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Telomerase interferes with this record keeping.
端粒酶干扰这一记录过程.
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Conclusion Telomerase is a tumor specific gene marker.
结论端粒酶是一种特异性的恶性肿瘤基因标志物.
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The Scientists scientists named the telomerase.
科学家将之命名为端粒酶.
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Telomerase, a ribonucleoprotein enzyme, is a key component in maintaining the development of malignant tumor.
端粒酶激活与恶性肿瘤发生发展之间存在着密切的关系.
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telomerase
"Ninety percent of all cancer cells are telomerase rich," Muller said.
"百分之九十的癌细胞都富含端粒酶，"穆勒说。
All 10 contral specimens were cytologically negative, but the TRAP-silver stained assay detected telomerase in two of them.
10例对照标本细胞学检查均为阴性，端粒酶活性测定2例阳性。
Telomerase activity was not present in 5 cases of breast fibrocystic disease.Weak telomerase activity was detected in 4 of 9 cases of breast fibroadenoma.
5例乳腺囊腺病无一例端粒酶活性，9例乳腺腺瘤中4例端粒酶弱阳性。
Telomerase activity of HO-8910 cells was significantly inhibited when treated with AZT, and cell cycle of treated HO-8910 cells was changed with marked increase in G 2/M phase.
AZT作用后的 HO-8910细胞端粒酶活性明显受抑制 ,且细胞的 G2 /M期 DNA含量明显增高 .
AZT can inhibit the telomerase activity and induce apoptosis of SMMC-7721 cells, which is related to specific small molecular proteins.
AZT可抑制SMMC-7721细胞端粒酶活性,诱导凋亡与相关特异小分子蛋白有关。
BCG CWS and IL 2 is effective in inhibiting the telomerase activity and in inducing cellular apoptosis for bladder cancer.
BCG CWS联合IL 2膀胱灌注能抑制肿瘤细胞端粒酶活性 ,诱导肿瘤细胞发生凋亡 ,具有明显的抗肿瘤作用
The different activity levels of telomerase were revealed using ELISA indi rect quantitative assays.
ELISA间接定量法能很好地反映不同程度的端粒酶活性状态。
These findings suggest that hTERT gene expression and telomerase activity may be valuable tumor maker for EOC early diagnosis but its prognostic value needs to be further studied.
hTERT表达及端粒酶活性可望作为有价值的肿瘤标志物而用于卵巢癌的早期诊断 ,但其预后价值尚有待于进一步研究。
Telomerase activity was determined by PCR MPH accurately and specifically in various tumor tissues, its sensitivity was one hundred times higher than that of PCR PAGE.
PCR- MPH方法能准确、特异地检测出肿瘤组织的端粒酶活性 ,其灵敏度比 PCR- PAGE法高 10 0倍。
Compared with c ells treated with t-BHP alone, Rg1 pretreatment markedly decreased the shorteni ng of RTF length and resulted in telomerase activation.
Rg1可明显减弱t BHP诱导细胞衰老的作用,减少t BHP引起的端粒长度缩短,同时可见细胞端粒酶活性的表达。
Significant difference of SPF was found between telomerase activity positive and negative groups, and between p53 mutation protein positive and negative groups.
SPF值在端粒酶活性阴性组、阳性组之间 ,p5 3突变蛋白阴性组、阳性组之间均有显著性差异。
Telomerase activity of GBC SD cells was examined by telomeric repeat amplification protocol (TRAP).
TRAP法检测端粒酶活性,流式细胞仪检测细胞周期及凋亡情况,电镜观察细胞微观形态变化。
The non-radioisotopic TRAP assay is a method feasible to detect telomerase activity.
TRAP银染法是一种值得推广的检测端粒酶活性的方法。
The scientists discovered the workings of telomerase, an enzyme that produces tiny units of DNA that seal off the tips of chromosomes.
三位科学家发现了端粒的工作机理，这种(酉每)可以产生DNA的微小部分，包裹染色体的顶端。
In the early 1980's Elizabeth Blackburn, Carol Greider and Jack Szostak identified telomerase and learned how it works.
上世纪八十年代初，伊利莎白*布拉克本、卡洛*格雷德及杰克*绍斯塔克三人识别出端粒酶，并了解其作用原理。
Compared to HTR, HTERT expression was better associated with telomerase activity with a concordance of 88.9%.
与HTR相比，HTERT同端粒酶具有更高的一致性，其一致率为88.9%。
At same time,the chan ges of the expression o f P53 oncogene and telomerase was were observed.
与此同时，P53表达和端粒酶活性发生变化。
The telomerase activities of HeLa,Tca-8113,YTLMC-90 and Eca-109 cells in vivro were investigated by TRAP-ELIAS technique.
为了进一步证实异鼠李素的抑癌抗癌作用，对其抑制肿瘤生长增殖和诱导肿瘤细胞凋亡的分子机制进行了实验研究。
For example, scientists are trying to reactivate telomerase to treat blindness, cardiovascular disease and neurodegenerative disease.
举例来讲，科学家们正试图重新激活端粒(酉每)来治疗失明、心血管疾病和神经退行性疾病。
Later, Mizz Blackburn and Mizz Greider discovered the substance in the body that builds telomeres. The scientists named the enzyme telomerase.
之后，伊丽莎白女士和绍斯塔克先生发现了在身体中制造颗粒的物质。科学奖们将它命名为端粒酶。
Activation of telomerase and prolonging of RTF length might be involved in t he process of ginsenoside Rg1 protection against t-BHP-induced senescence in W I-38 cells.
人参皂苷Rg1可能通过激活端粒酶活性和减少端粒长度缩短而发挥其抗t BHP诱导的WI 38细胞衰老作用。
These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase.
他们的发现解释了染色体末端是怎样得到端粒的保护，而端粒是在端粒酶的作用下形成的。
Their research showed that cells age if telomeres are shortened. But, cell death is delayed if a lot of the enzyme telomerase is produced.
他们的研究显示如果端粒缩短细胞就将变老。但是，如果有端粒酶大量产生的话，细胞死亡将延迟。
Telomerase is capable of synthesizing telomeric DNA onto the ends of chromosomes, compensating the telomeric sequences lost and making cell immortal.
但端粒酶的存在却可以维持细胞端粒的长度,使细胞可以逃避凋亡而具有“不死性”。
Counter C M, Gupta J, Harley C B, et al. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood,1995,85:2315.
何冬梅,张洹.端粒酶基因反义核酸促进顺铂诱导白血病细胞凋亡.中华内科杂志,2001,40(10):654.
For example, some research suggests that cancer cells use telomerase to grow uncontrollably.
例如，一些科学研究表明，癌细胞利用端粒酶增长失控。
The clinical significance of diagnosing acute lymphoblastic leukemia by determining telomerase activity in extracts of peripheral blood mononuclear cells in childhood.
儿童周围血单个核细胞端粒酶活性检测在诊断急性淋巴细胞白血病中的临床意义。
Title： The relationship between telomerase activity and the expression of proliferating cell nunclearnatigen of squamous cell carcinomas.
关键词：癌；癌旁上皮；端粒酶；增殖细胞核抗原
One of chromosome telomere behavior and abnormal expression of telomerase play an important role in tumor formation.
其中染色体端粒行为及端粒酶表达异常在肿瘤形成中扮演重要角色。
The capybara, nearly the size of a grown human, was not expressing telomerase, suggesting eolution was willing to forgo the benefits in order to reign in cancer.
几乎和**体重相当的水豚并不表达端粒酶，说明进化还是更乐于放弃复原的益处而到达对癌症的控制。
The capybara, nearly the size of a grown human, was not expressing telomerase, suggesting evolution was willing to forgo the benefits in order to reign in cancer.
几乎和成人体重相当的水豚并不表达端粒酶，说明进化还是更乐于放弃复原的益处而到达对癌症的控制。
Several companies, including Geron, have started testing drugs that gum up the telomerase enzyme, so that it can't extend the lives of cancer cells.
包括杰龙公司在内的几家公司已开始进行抑制端粒酶酵素的药物试验，使之不能延长癌细胞的生命。
There were no significant correlation among the general positive rate of telomerase activity histological substypes,histological gr ades or tumor stages.
卵巢上皮性恶性肿瘤组织中，在组织类型、组织学分级及肿瘤分期之间无显著性差异。
Hur K,Gazdar AF,Rathi A,et al. Overexpression of human telomerase RNA in Helicobacter pylori-infected human gastric mucosa[J]. Cancer Res, 2000,91 ( 11 ): 1148.
司君利,刘吉勇,元玉琴.幽门螺杆菌感染与胃粘膜端粒酶活性关系的研究[J].世界华人消化杂志,1999,7(5):429.
In 83.3%of the cases examined, exfoliated cells showing cytological dysplasia were found to be telomerase activity positive.
同时还测得83.3%的肺脱落细胞不典型增生者的端粒酶活性水平也显著增高。
Blackburn and Ms.Greider discovered the substance in the body that builds telomeres.The scientists named the enzyme telomerase.
后来布莱克本和格雷德发现了人体中用来构筑端粒的物质，并将之命名为端粒酶。
Bodnar AG,Ouellette M,Frolkis M,et al.Extension of lifespan by introduction of telomerase into normal human cells [J].Science,1998,27 (5349):349.
向娟娟,朱诗围,吕红斌,等.用氧化铁磁性纳米颗粒作为基因载体的研究[J].癌症,2001,20(10):1009.
Hiyama E, Yokoyama T, Tatsumoto N, et al. Telomerase activity in gastric cancer [J ]. Cancer Res, 1995,55 (15):3258.
吴珊,刘宗石,李晓明,等.原发性肝癌及慢性肝脏病变端粒酶活性的研究[J].中华病理学杂志,1998,27(2):91.
Therefore, to control the activity of telomerase effectively may give a new way for people to surmount c...
因此,有效地控制端粒酶活性,有可能为人类攻克癌症提供一个新的契机。
In adults, almost all of the cells that produce telomerase are cancerous.
在成年人中，几乎所有产生端粒酶的细胞都是癌细胞。
We summarize the present research of telomerase and telomere and their applications on ocular disease.
在此,我们就端粒、端粒酶研究现状及其与眼科疾病的关系和应用进展作一综述。
Why is this important" In embryonic cells (and some stem cells), an enzyme called telomerase rebuilds the telomere so that the cells can keep dividing.
在胚胎细胞（还有一些干细胞），一种叫做端粒末端转移酶的酶可以重建端粒，以便细胞能保持分裂。
A lot of research has indicated that telomerase system has important effect upon eye in cells' aging and proliferation.
大量研究表明,端粒酶的活性与眼部组织的增生、细胞的衰老及眼部肿瘤的发生关系密切。
To her surprise, she found no correlation between telomerase and longeity.
她惊奇地发现，端粒酶与寿命并不存在相关性。
If a 160-pound human must give up telomerase to thwart cancer, then what does a 250,000-pound whale have to do to keep its risk of cancer at bay?
如果160磅的人类必须通过放弃端粒酶来阻挠癌症的发生，那么海里250,000磅的鲸鱼有将如何来控制它们得癌症的几率呢?
However, that in the tumor-adjacent tissues was 10% (2 out of 20 specimens) and no telomerase activity was observed in 5 tuberculous tissues or cells.
对照组：癌旁组织中端粒酶阳性率为10%(2/20)，肺结核瘤组织及细胞的端粒酶表达均呈阴性。
This paper made a summary of the recent researches on the structure and function of telomere and telomerase as well as the relation between telomerase and tumors.
对近年来端粒、端粒酶的结构与功能、端粒酶与肿瘤的关系进行了综述。
It has proved that telomerase express increased abnormally in (84.7%) human tumor tissues and cells.
已证明有84.7%的人类恶性肿瘤组织细胞中端粒酶表达异常增高.
Not much is known about CRR9 but pinpointing the TERT gene is promising because it activates an enzyme called telomerase which is key to aging and cancer, Brennan said.
布伦南指出对于CRR9所知甚少但研究发现TERT是非常可能同肺癌相关,TERT会激活对于衰老和癌变非常重要的端粒酶。
The effect of bleomycini therapy on the telomerase activity of oral cancer patients.
平阳霉素化疗对口腔癌患者端粒酶活性的影响。
Results:Oridonin could decrease the activity of telomerase, as well as cause apoptosis and inhibit the growth of K562 cells significantly.
并呈现出明显的量-效与时-效关系。
Telomerase activity was determined by the telomeric repeat amplification protocol enzyme-linked immunoassay (TRAP -ELISA).
应用TRAP-ELISA法测定肾上腺肿瘤中的端粒酶活性。
Rhyu MS.Telomere、telomerase and immortality[J].J Natl Cancer Inst,199 5,87:884.
张方信，张学庸，樊代明.端粒酶的结构、功能与肿瘤的靶向治疗[J].中国肿瘤生物治疗杂志，1996，3：321.
Kim NW,Piatyszek MA,Prowse KR,et al.Specific association of human telomerase activity immortal cells and cancer[J].
张松岩,付震,刘宏毅,等.脑星形细胞肿瘤端粒酶活性与S期细胞比例相关性研究[J].肿瘤研究与临床,2000;
The combinational detection of circulating DNA and telomerase of circulating tumor cells is useful for the early diagnosis of tumors.
循环DNA和肿瘤细胞端粒酶的联合检测,对于肿瘤早期诊断有重要意义。
The abnormal expression of oncoprotein P53 and P16 as well as the increase of telomerase are closely related to the occurrence and development of bowenoid papulosis.
感染细胞致癌蛋白p53和p16的异常表达、端粒酶活性的增高与鲍恩样丘疹病的发生发展密切相关。
What we need to do for WILT is actually delete (or at least seriously disrupt) the telomerase genes.
我们为WILT所须做的，实际上是删除（或至少是严重破坏）端粒酶基因。
What we need to do for WILT is actually delete( or at least seriously disrupt) the telomerase genes.
我们为wilt所须做的，实际上是删除（至少是严重破坏）粒酶基因。
Thus we used MD tumor as research model and investigated the mechanism of MDV oncoginisis by researching telomere ,telomerase , tumor suppressors of chicken and MDV oncogene .
我们以MD肿瘤为模型，从端粒及端粒酶、肿瘤抑制因子、MDV的相关致瘤基因等的研究入手，对MDV的致瘤机理进行了研究。
For example, helicase and telomerase, are drug targets for controlling virus replication and cancer cell survival.
我们期待综合蛋白质结构与动态的资讯将有助了解基本生化过程的机制及设计酵素抑制剂.
Abstract： Objective To study the effect of telomerase antisense RNA on telomerase activity and cell proliferation of HL-60 cells.
摘 要： 目的 探讨端粒酶反义RNA对HL-60细胞端粒酶活性及细胞增殖的影响。
Abstract Purpose: To study the clinical significance of the expression of telomerase activity in sputa of lung cancer patients.
摘要 目的：分析研究肺癌患者痰液端粒酶活性表达的临床意义。
The telomerase activity in mouse oocyte and preimplantation embryo was examined using the polymerase chain reaction-based on telomeric repeat amplification protocol (TRAP).
摘要为了解小鼠早期发育过程中端粒酶的活性变化，本研究利用端粒重复序列扩增法(TRAP)进行了小鼠卵母细胞和附植前胚胎端粒酶活性的测定。
Objective To study the telomerase and serum lactic dehydrogenase (LDH) activity in acute leukemia and explore its significance.
摘要目的探讨急性白血病端粒酶和乳酸脱氢酶活性的变化及其临床意义。
Objective: To compare the value of diagnosis between telomerase activity (TA) and CEA in diagnosing malignant ascites.
摘要目的：比较端粒酶活性(TA)和癌胚抗原(CEA)指标诊断恶性腹水的价值。
The Telomeric Repeat Amplification Protocol (TRAP) and its modified versions change the size and/or the ratio of the telomerase products in the amplification stage of the assay.
摘要：端粒酶活性直接与细胞的分生能力、生活力、生命力有着密不可分的关系， 因此对其活性测定有着重要意义。
Abstract: Objective To investigate the role of telomerase activity in the oncogenesis and progression of human lung cancer.
文摘:目的探讨端粒酶活性表达与肺癌发生发展的关系。
Abstract: Objective To investigate telomerase activity in patients with psoriasis.
文摘:目的探讨银屑病的端粒酶活性表达情况。
Methods:We used telomerase PCR MPH,an assay in which a digoxigenin labeled telomerase repeat specific probe was hybridized to the PCR product.
方法:PCR-MPH以地高辛标记端粒重复片段特异的探针与PCR变性产物杂交,经酶底物显色,通过测定吸光度判断结果;
Methods:Telomerase activity was detected by a TRAP-PCR-ELISA assay in tissue samples from 36 gastric carcinomas, 20 gastric ulcer, 10 gastritis, and 20 normal gastric muccosa.
方法:应用TRAP-PCR-ELISA方法检测36例胃癌组织,20例胃溃疡组织,10例胃炎组织和20例正常人胃黏膜组织中端粒酶的活性。
Methods:To review the up to date progresses of telomerase in recent years throughout the world.
方法回顾近几年国内外端粒酶研究的最新进展。
Method To pathomorphism diagnose and telomerase activity test to same specimens of same cases, then analysis their results of two methods.
方法用相同患者的相同组织块分别行病理形态学诊断和端粒酶活性检测,将二者结果进行对照分析。
Methods Telomerase activity was examined in 37 brain tumor tissues and 4 normal human brain tissues by telomeric repeat amplification protocol(TRAP) assay and silver staining.
方法采用TRAP-银染法检测了37例脑肿瘤组织和4例正常脑组织中的端粒酶活性。
Methods 81 human lung specimens,comprising 50 carcinoma tissues,24 chronic mucitis tissues and 7 metaplasia or atypia tissues,were examined for telomerase activity by TRAP assay.
方法采用TRAP法检测了81例纤维支气管镜活检组织端粒酶活性,包括50例肺癌组织,24例慢性粘膜炎组织,7例化生、不典型增生组织。
Methods Telomerase activity and CYFRA21 1 from pleural effusion of 31 lung cancer cases and 33 non malignant pleural effusion cases were detected by PCR ELISA and IRA.
方法采用聚合酶链反应 -酶联免疫吸附分析法 (PCR-ELISA)检测胸液端粒酶活性和免疫放射分析法测定胸液 CYFRA2 1-1水平 ,共检测了 3 6例肺癌胸腔积液和 3 3例非恶性胸腔积液。
Methods:We used telomerase PCR-MPH，an assay in which a digoxigenin-labeled telomerase repeat-specific probe was hybridized to the PCR product.
方法：PCR-MPH以地高辛标记端粒重复片段特异的探针与PCR变性产物杂交，经酶底物显色，通过测定吸光度判断结果；
Methods Telomerase activity express and serum CA(subscript 125) level of 42 cases of ovarian tumor were detected by TRAP-ELISA and radioimmunoassay.
方法：以42例卵巢肿瘤患者为研究对象，行TRAP-ELISA方法检测肿瘤组织中端粒酶活性，同时以放射免疫法检测其血清CA（下标125）值。
Methods：Telomerase activities were examined in 33 cases of esophageal carcinomas and 18 tumor-adjacent tissues by TRAP assay.
方法：应用TRAP法对33例食管癌及18例癌周正常食管粘膜进行端粒酶活性测定。
Methods: The sputa of 30 lung cancer patients and 25 benign lung disease patients(control group) were checked for telomerase activity with PCR-TRAP ELISA.
方法：运用端粒酶PCR-TRAP酶联免疫吸附试验(ELISA)测定法对30例肺癌患者及25例肺部良性疾病患者(对照组)的痰液进行端粒酶活性检测。
Methods:The expression of telomerase activity in cancer,paracancer and normal tissue in 51 patients with gastric carcinoma were detected by TRAP-ELISA method.
方法：采用TRAP-ELISA法检测了51例胃癌组织、癌旁及远端正常胃组织的端粒酶活性表达。
用作名词(n.)To her surprise, she found no correlation between telomerase and longeity.
她惊奇地发现，端粒酶与寿命并不存在相关性。
Telomere and telomerase play important roles in the process of cellular senescence.
端粒及端粒酶在细胞的衰老过程中扮演着重要角色。