dystrophin单词基本解析：

肌萎缩蛋白

释义肌萎缩蛋白；

dystrophin变化用词：

dystrophin英英释义：

DystrophinDystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the dystrophin-associated protein complex.

以上来源于:Wikipedia

dystrophin中文词源：

dystrophin用法和例句：

dystrophin

Intron 44 is not the most unstable intron in the "central deletion hot spot" of dystrophin gene

44号内含子并非是dystrophin基因中央缺失热区最不稳定的内含子

Genetic Analysis of 60 Duchenne Muscular Dystrophy (DMD) or Becker Muscular Dystrophy (BMD) Patients Using Dystrophin cDNA

60例 DMD/BMD 患者用抗肌营养不良 cDNA 探针的基因分析

Changes of dystrophin expression in muscle of patients with DMD and its relevance to clinical pathology

DMD患者骨骼肌抗肌萎缩蛋白表达与临床病理改变

DMD is caused by a mutation of the gene for dystrophin, a protein in the muscles.

DMD源于肌肉中一种称为肌营养不良蛋白的基因突变。

dystrophin protein

dystrophin蛋白

None of the fibers expression dystrophin was stained with Evans blue.

Evans蓝染部分没有dystrophin表达。

Mutation analysis of dystrophin gene and clinical evaluation of phenotypes in X-linked dilated cardiomyopathy

X-连锁扩张型心肌病患者杜兴氏肌营养不良基因突变分析及临床评价

Three to four weeks later, each injected muscle was biopsied and examined for evidence of dystrophin production.

三至四个星期后，每个注射肌肉活检和审查的证据，抗肌萎缩蛋白的生产。

Distributional characteristics of dystrophin gene deletion in Chinese population

中国人抗肌营养不良蛋白基因缺失的分布特点

There are some small errors in the genetic code on the gene which means that it is unable to produce the dystrophin protein which keeps muscles strong.

也有一些小失误，在遗传密码的基因，这意味着它无法产生抗肌营养不良蛋白的蛋白质保持肌肉强劲。

human dystrophin gene

人类肌营养不良基因

Biopsies from muscles injected with the higher dose of test drug showed an unequivocal, widespread and robust response in terms of number of dystrophin positive muscle fibers.

从肌肉切片注射高剂量的药物试验显示，一个明确，广泛和有力的反应方面的一些积极的肌纤维肌营养不良蛋白。

Dystrophin, the protein missing in Duchenne muscular dystrophy patients, conducts this energy across the muscle cell's membrane, protecting the fiber.

但肌节产生的力量，如果没有向外引导的话，也会伤害肌纤维，DMD患者所缺乏的肌肉萎缩蛋白，能将这股力量传导到肌肉细胞膜上，而保护肌纤维。

Keywords Duchenne and Becker muscular dystrophy;Dystrophin;Twins;

假肥大肌营养不良;肌营养不良蛋白;双生子;

Keywords DMD;BMD;gene;exon;multiplex-PCR;dystrophin;immunofluorescence technique;

关键词DMD;BMD;基因;外显子;多重PCR;抗肌营养不良蛋白;免疫荧光技术;

The membrane of muscle cell didn't show dystrophin in 10 cases of 12 DMD (83.33%).

在DMD中有10例（83.33%）肌细胞膜肌营养不良蛋白不表达。

In experiments in mice and in cells derived from DMD patients, production of the muscle protein dystrophin has been restored despite the presence of errors (mutations) in the dystrophin gene.

在针对老鼠和来自DMD患者的细胞实验中，研究结果是，抗肌萎缩蛋白得以修复----尽管仍存在抗肌萎缩蛋白基因的突变。

It would not be suitable for treating different mutations in the dystrophin gene, or diseases not caused by nonsense mutations.

它对肌营养不良基因的其他类型的变异或非无意突变导致的疾病无效。

When compared to the level of dystrophin in normal muscle fibers, the dystrophin content per patient fiber went from 5% pre-treatment to 37% in the post-treatment biopsy.

当相比，在正常肌纤维肌营养不良蛋白的水平，每名病人纤维肌营养不良蛋白含量从5%到治疗前的37%治疗后活检。

In general, and in this study, DMD patients have less than 5% dystrophin positive muscle fibers prior to treatment.

总体上，在这项研究中，营养不良患者有小于5%抗肌萎缩蛋白阳性肌纤维前处理。

truncated isoform of dystrophin

截短型营养不良

The gene for dystrophin is among the largest known, and miniaturizing it, while retaining the crucial elements of its set of DNA instructions, has been one of the greatest challenges to the field.

抗肌肉萎缩蛋白基因是已知较大基因的一种，截短该基因的长度并保留维持这个基因片断的重要结构的部分片段，是这项研究中最具挑战性的工作。

Keywords Dystrophin gene;De novo mutation;Genital gland chimera;Gene deletion;

抗肌萎缩蛋白基因;新生突变;生殖腺嵌合;基因缺失;

Keywords dystrophin gene;junction fragments;introns;gene deletion;

抗肌萎缩蛋白基因;连接片段;内含子;基因缺失;

CORRELATION BETWEEN THE HYDROPHOBIC STRUCTURE OF DYSTROPHIN AND DMD/BMD

抗肌萎缩蛋白的疏水结构与DMD/BMD的关系

Abstract： Objective To investigate the significance on the expression of dystrophin in muscle tissue of the patients with myodystrophy.

摘 要： 目的 探讨肌营养不良蛋白在肌营养不良症患者肌组织中表达的意义。

Methods Deletion analysis of the probands was performed by multiplex polymerase chain reaction (PCR) to amplify 9 dystrophin exons described by Chamberlain.

方法 用多重聚合酶链反应方法扩增dystrophin基因 9个外显子 ,检测先证者有无外显子缺失 ;

Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while thosewith Becker muscular dystrophy have dystrophinof an altered size.

是最常见的一类进行性肌营养不良症。

Keywords Duchenne muscular dystrophy（DMD） Becker muscular dystrophy（BMD） Dystrophin Arrector pili muscle Sarcolemma;

杜兴型肌营养不良;贝克型肌营养不良;肌营养不良蛋白;立毛肌;肌纤维膜;

Duchenne muscular dystrophy and Becker's muscular dystrophy are caused by mutations of the gene for the dystrophin protein and lead to an overabundance of the enzyme creatine kinase .

杜氏肌营养不良和贝克尔的肌营养不良症是由基因突变基因的抗肌萎缩蛋白，并导致过多的酶肌酸磷酸激酶。肌营养不良蛋白基因是最大的人类基因。

It's caused by a mutation in the gene that makes dystrophin, a protein that enables muscle contraction.

此病的病因是由生产dystrophin的基因发生突变引起的。 Dystrophin是一种能使肌肉收缩的蛋白质。

Yet even with dystrophin's buffering, muscle fibers are still injured by normal use.

然而即使有肌肉萎缩蛋白的缓冲效应，肌纤维在正常运作下仍然会受伤。

Patients with DMD have a very low capacity to make dystrophin.

症患者有一个非常低的能力，使肌营养不良蛋白。

The Asklepios researchers plan to insert a proprietary miniaturized version of the dystrophin gene into an adeno-associated viral vector designed to deliver the gene to human muscles.

目前没有使肌肉停止病变和逆转的有效的治疗方法。

Objective To establish a simple and reliable method to examine the detection of dystrophin gene in patients and carriers with Duchenne muscular dystrophy (DMD) to lay a foundation for prenatal diagnosis.

目的 建立一种简便、可靠的缺失型Duchenne型肌营养不良(DMD)患儿及携带者的基因检测方法,为DMD产前诊断的开展奠定基础。

Objective: To analysis the deletion distribution of dystrophin gene and the relationship between gene deletions and clinical symptoms in Duchenne/Becker muscular dystrophy (DMD/BMD).

目的:了解Duchenne/Becker型肌营养不良症(DMD/BMD)致病基因缺失的分布及其与临床病情的关系。

Objective: To study the distributive characteristics of dystrophin gence deletion and the relationship between the number of deletion and clinical symptoms in Duchenne/Becker muscular dystrophin (DMD/BMD).

目的:研究Duchenne/Becker型肌营养不良症(DMD/BMD)患者致病基因外显子缺失的分布特点及其与临床表现的关系。

Objective To detect dystrophin gene deletion of Duchenne muscular dystrophy (DMD) and make DMD gene diagnosis.

目的探讨Duchenne型肌营养不良症（DMD）患者基因缺失的突变特点并进行基因诊断。

Conclusion The absence or abnormal expression of dystrophin was the specific change for DMD/BMD.

结论 肌营养不良蛋白的缺失或异常表达，是DMD/BMD型较为特异的改变。

Comparison and analysis of the molecular character of breakpoints in introns of deletion hotspots of dystrophin gene

缺失型杜氏肌营养不良症缺失热区内含子断裂点分子结构特点的对比分析

Immunofluorescent analysis of the muscle biopsies from this patient showed an increase in the percentage of dystrophin positive muscle fibers from 1% pre-treatment to 21% in the post-treatment biopsy.

肌肉活检的免疫荧光分析显示，从该病人从1%的前处理中的肌营养不良积极肌肉纤维增幅在治疗后活检的21%。

Association between dystrophin and neuronal nitric oxide synthase in muscles of progressive muscular dystrophy

肌营养不良症患者肌肉中肌营养蛋白与神经元型一氧化氮合酶相互关系的研究

DNA ;Dystrophin ;Matrix Attachment Regions ;Nucleic Acid Conformation ;

肌营养不良蛋白 ;

EXPRESSION OF DYSTROPHIN IN MUSCLE TISSSUES OF DUCHENNE AND BECKER MUSCULAR DYSTROPHY TWINS

肌营养不良蛋白在假肥大肌营养不良双生子肌组织中的表达

A study of dystrophin expressions in muscle tissues of patients with Duchenne-Becker muscular dystrophy

肌营养不良蛋白在假肥大肌营养不良症肌组织中的表达研究

dystrophin gene

肌营养不良蛋白基因

Restoration of functional dystrophin expression is considered critical for successful treatment of DMD.

肌营养不良蛋白的表达功能恢复被认为是DMD的治疗成功的关键。

Under a fluorescence microscope, the number of fiber stained with Evans blue and dystrophin was counted, analyzed quantitatively with image software.

荧光显微镜下,观察Evans蓝和dystrophin阳性纤维数,图像分析比较。

P-dystrophin see pukinje cell dystrophin

蒲肯野氏细胞营养不良

Though the mini-gene puts out less dystrophin than the full size version, it seems to enable muscle contraction all the same.

虽然简约化的基因生产出的dystrophin比完整大小基因少，但是好像能同样有效地使肌肉收缩。

The expression of dystrophin in muscle tissue was examined by immunohistochemitry,it could be a specific index for the diagnosis of DMD/BMD.

运用免疫组化法检测患者肌组织中肌营养不良蛋白的表达，可为DMD/BMD型的病理诊断提供特异性指标。

This enables the gene to produce a working version of the dystrophin gene.

这使得该基因产生的一个工作版本的抗肌营养不良蛋白基因。

DMD occurs when a gene on the X chromosome fails to make the essential muscle protein dystrophin.

这种疾病的病因是在X染色体上的一个基因不能表达抗肌肉萎缩蛋白。

It is important to note that different mutations in the dystrophin gene require different oligonucleotide drugs.

重要的是要注意到，不同的突变，抗肌萎缩蛋白基因，需要不同的寡核苷酸药物。

By injecting mice with the mini-dystrophin-carrying vector, Chamberlain and colleagues were able to deliver dystrophin to such muscles as the heart, diaphragm and all the limb muscles.

（通过用携带微型dystrophin的菌体注射老鼠，Chamberlain和同事们能够传送dystrophin给类似于心脏、横膈膜和各种肢体的肌肉。

Besides the mini-dystrophin package, the new delivery system includes a growth factor called VEGF that increases the ability of dystrophin to penetrate into muscle cells.

（除了微型dystrophin包外，新的传送系统包括了一种称为VEGF的生长因素，它能增大dystrophin穿入肌肉细胞的能力。）

用作名词(n.)

Patients with DMD have a very low capacity to make dystrophin.
症患者有一个非常低的能力，使肌营养不良蛋白。

This enables the gene to produce a working version of the dystrophin gene.
这使得该基因产生的一个工作版本的抗肌营养不良蛋白基因。

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